Creamy Chicken and Stuffing Casserole

There’s something undeniably comforting about a warm, hearty casserole straight from the oven. This Creamy Chicken and Stuffing Casserole is the ultimate comfort food—layers of tender chicken, rich cream sauce, and savory stuffing come together in a dish that’s both nostalgic and irresistibly delicious. Whether you’re feeding a busy family or hosting a cozy dinner, this recipe is a guaranteed hit. Let’s dive into why this casserole deserves a spot in your weekly meal rotation.

Why You’ll Love This Recipe

If you’re looking for a dish that’s easy to prepare yet delivers big on flavor, this Creamy Chicken and Stuffing Casserole checks all the boxes. Here’s why it’s a must-try:

Comfort food at its finest – The combination of creamy sauce, juicy chicken, and buttery stuffing creates a satisfying texture and taste that feels like a warm hug.

Effortless prep – With simple ingredients and minimal hands-on time, this recipe is perfect for weeknights or meal prep.
Crowd-pleasing versatility – It’s a hit with kids and adults alike, and you can easily customize it to suit different tastes.
Leftovers taste even better – The flavors meld beautifully overnight, making it an excellent make-ahead dish.

One-dish wonder – Less cleanup means more time to enjoy your meal and relax.

Ingredients Breakdown

Every ingredient in this Creamy Chicken and Stuffing Casserole plays a crucial role in building layers of flavor and texture. Here’s what you’ll need and why it matters:

Chicken breast or thighs – Boneless, skinless chicken breasts work well for a leaner option, but thighs add extra juiciness and richness.

Cream of chicken soup – This pantry staple forms the base of the creamy sauce, adding depth and convenience.
Sour cream – It lends a tangy creaminess that balances the richness of the soup.
Stuffing mix – A classic herb-seasoned stuffing mix provides that beloved crispy-on-top, soft-underneath texture.

Chicken broth – Moistens the stuffing and enhances the overall savory profile.
Butter – Melted butter brushed over the stuffing creates a golden, crispy topping.
Seasonings – Garlic powder, onion powder, and black pepper add subtle layers of flavor.

How to Make Creamy Chicken and Stuffing Casserole

Follow these simple steps to create a dish that’s sure to become a family favorite:

Preheat your oven to 375°F and lightly grease a 9×13-inch baking dish.
Prepare the chicken by cutting it into bite-sized pieces. Season with salt, pepper, garlic powder, and onion powder.

Make the creamy sauce by combining the cream of chicken soup and sour cream in a bowl. Stir until smooth.
Layer the chicken evenly in the baking dish, then pour the creamy sauce over the top, ensuring all pieces are coated.
Prepare the stuffing by mixing the dry stuffing mix with chicken broth in a separate bowl. Let it sit for a few minutes to absorb the liquid.

Top the casserole with the stuffing mixture, spreading it evenly. Drizzle melted butter over the top for extra crispiness.
Bake uncovered for 30–35 minutes, or until the chicken is cooked through and the stuffing is golden brown.
Let it rest for 5–10 minutes before serving to allow the flavors to settle.

Pro Tips for the Best Results

Want to take your Creamy Chicken and Stuffing Casserole to the next level? Try these expert tips:

Use homemade cream sauce if you prefer—replace canned soup with a roux-based sauce made with butter, flour, and chicken stock.
Add veggies like sautéed mushrooms, spinach, or peas for extra nutrition and texture.

Toast the stuffing mix lightly before adding it to the casserole for an even crunchier topping.
Don’t overmix the stuffing—just moisten it enough to hold together without becoming mushy.
Check for doneness by ensuring the chicken reaches an internal temperature of 165°F.

Variations and Substitutions

This recipe is wonderfully adaptable. Here are some ways to make it your own:

Turkey instead of chicken – Leftover Thanksgiving turkey works beautifully in this dish.
Gluten-free option – Use gluten-free stuffing mix and a gluten-free cream soup substitute.

Dairy-free version – Swap sour cream for coconut cream and use a dairy-free butter alternative.
Cheesy twist – Sprinkle shredded cheddar or mozzarella between the chicken and stuffing layers.
Herb boost – Fresh thyme, rosemary, or sage can elevate the stuffing’s flavor.

What to Serve With It

This casserole is a complete meal on its own, but pairing it with the right sides can make it even more special:

Green vegetables – Steamed green beans, roasted Brussels sprouts, or a crisp salad add freshness.
Crusty bread – A warm baguette or garlic bread is perfect for soaking up extra sauce.

Cranberry sauce – A dollop adds a sweet-tart contrast to the savory flavors.
Light white wine – A crisp Chardonnay or Pinot Grigio complements the creamy richness.

How to Store and Reheat

This casserole keeps well, making it great for meal prep or leftovers:

Refrigeration – Store in an airtight container for up to 3 days.
Freezing – Wrap tightly or use a freezer-safe dish for up to 2 months. Thaw overnight before reheating.
Reheating – Warm in the oven at 350°F until heated through (about 20 minutes). For single servings, the microwave works but may soften the stuffing.

Frequently Asked Questions (FAQs)

Here are answers to common questions about this Creamy Chicken and Stuffing Casserole:

Can I use homemade stuffing instead of a mix?

Absolutely! If you have leftover homemade stuffing or prefer making it from scratch, just reduce the broth slightly to avoid excess moisture.

Can I make this ahead of time?

Yes, assemble the casserole up to a day in advance, cover, and refrigerate. Add 5–10 minutes to the baking time if starting cold.

Why is my stuffing soggy?

Too much liquid or overmixing can cause sogginess. Use just enough broth to moisten the stuffing without soaking it.

Can I use cream of mushroom soup instead?

Definitely! Cream of mushroom or celery soup can be substituted for a slightly different but equally delicious flavor.

Final Thoughts

This Creamy Chicken and Stuffing Casserole is more than just a meal—it’s a comforting, nostalgic dish that brings people together. Whether you’re serving it at a family dinner or bringing it to a potluck, its creamy, savory goodness is always a hit. I love how versatile it is, allowing for endless variations to suit any taste or dietary need. Give it a try, and I’m sure it’ll become a cherished recipe in your home too. Happy cooking!